Chapters | Patents

Articles

2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997

2018

Michnick SW and Bergeron-Sandoval, LP. Why Does Biopolymer Condensation Matter? Nat Rev Mol Cell Biol, 2018. In press.  Additional references.

2017

Kelil A, Dubreuil B, Levy ED and Michnick SW. Exhaustive search of linear information encoding protein-peptide recognition. Plos Comput Biol, 2017. 13 (4). Doi: 10.1371/journal.pcbi.1005499. pdf.

Abd-Rabbo D and Michnick SW. Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast. BMC Syst Biol, 2017. 11 (1):38. Doi: 10.1186/s12918-017-0418-0. pdf.

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2016

Li C, MacDonald J, Talebian A, Leuenberger J, Seah C, Pasternak SH, Michnick SW and Meakin S. Unravelling the mechanism of TrkA-induced cell death by macropinocytosis in medulloblastoma daoy cells. Mol Cell Biol, 2016. Doi: 10.1128/MCB.00255-16. pdf.

Bergeron-Sandoval LP, Safaee N and Michnick SW. Mechanisms and consequences of macromolecular phase separation. Cell, 2016. 165 (5):1067–79. pdf.

Kelil A, Levy ED and Michnick SW. Evolution of domain-peptide interactions to co-adapt specificity and affinity to functional diversity. PNAS USA, 2016. 113 (27):E3862-71. pdf.

Sivanesan D, Beauchamp C, Quinou C, Lee J, Lesage S, Chemtob S, Rioux JD and Michnick SW. IL23R variants protective against inflammatory bowel diseases (IBD) display loss of function due to impaired protein stability and intracellular trafficking. J Biol Chem, 2016. pii: jbc.M116.715870. pdf.

Sánchez-Fernández G, Cabezudo S, Caballero Á, García-Hoz C, Tall GG, Klett J, Michnick SW, Mayor FJ and Ribas CJ. Protein kinase C ζ interacts with a novel binding region of Gαq to act as functional effector protein. J Biol Chem, 2016. pii:jbc.M115.684308. pdf.

Ear PH, Kowarzyk J, Booth MJ, Abd-Rabbo D, Shulist K, Hall C, Vogel J and Michnick SW. Combining the optimized yeast cytosine deaminase protein fragment complementation assay and an in Vitro Cdk1 targeting assay to study the regulation of the γ-tubulin complex. Methods Mol Biol, 2016. 1342:237-57.

Michnick SW, Landry CR, Levy ED, Diss G, Ear PH, Kowarzyk J, Malleshaiah MK, Messier V and Tchekanda E. Protein-fragment complementation assays for large-scale analysis, functional dissection, and spatiotemporal dynamic studies of protein-protein interactions in living cells. Cold Spring Harb. Protoc, 2016. doi:10.1101:pdb.top083543.

Michnick SW, Levy ED, Landry CR, Kowarzyk J and Messier V. The dihydrofolate reductase protein-fragment complementation assay: a survival-selection assay for large-scale analysis of protein-protein interactions. Cold Spring Harb. Protoc, 2016. doi:10.1101:pdb.prot090027.

Ear PH, Kowarzyk J and Michnick SW. Dissecting the contingent interactions of protein complexes with the optimized yeast cytosine deaminase protein-fragment complementation assay. Cold Spring Harb. Protoc, 2016. doi:10.1101:pdb.prot090043.

Malleshaiah M, Tchekanda E and Michnick SW. Real-time protein-fragment complementation assays for studying temporal, spatial and spatiotemporal dynamics of protein–protein interactions in living cells. Cold Spring Harb. Protoc, 2016. doi:10.1101:pdb.prot090068.

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2015

Röck R, Bachmann V, Bhang HE, Malleshaiah M, Raffeiner P, Mayrhofer JE, Tschaikner PM, Bister K, Aanstad P, Pomper MG, Michnick SW and Stefan E. In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs. Sci Rep, 2015. 5 :11133. pdf.

Remy I and Michnick SW. Mapping biochemical networks with protein fragment complementation assays. Methods Mol Biol, 2015. 1278 467-81.

Kanshin E, Bergeron-Sandoval LP, Isik SS, Thibault P and Michnick SW. A cell-signaling network temporally resolves specific versus promiscuous phosphorylation. Cell Rep, 2015. 10 (7):1202-14. pdf.

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2014

Quiniou C, Domínguez-Punaro M, Cloutier F, Erfani A, Ennaciri J, Sivanesan D, Sanchez M, Chognard G, Hou X, Rivera JC, Beauchamp C, Charron G, Vilquin M, Kuchroo V, Michnick SW, Rioux JD, Lesage S and Chemtob S. Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response. Am J Physiol Regul Integr Comp Physiol, 2014. 307 (10):R1216-30. pdf.

Kelil A, Dubreuil B, Levy ED and Michnick SW Fast and accurate discovery of degenerate linear motifs in protein sequences. PLoS One, 2014. 9 (9): e106081. pdf, MotifHound.

Levy ED, Kowarzyk Moreno J and Michnick SW High-resolution mapping of Protein concentration reveals principles of proteome architecture and adaptation. Cell Rep, 2014. 7 (4):1333-40. pdf.

Tchekanda E, Sivanesan D, and Michnick SW. An infrared reporter to detect spatiotemporal dynamics of protein-protein interactions. Nat Methods, 2014. 11 (5):641-4. pdf.

Chognard G, Bellemare L, Pelletier AN, Dominguez-Punaro MC, Beauchamp C, Guyon MJ, Charron G, Morin N, Sivanesan D, Kuchroo V, Xavier R, Michnick SW, Chemtob S, Rioux JD, Lesage S. The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation. Plos One, 2014. 9 (2):e89092. pdf.

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2013

Landry CR, Levy ED, Abd-Rabbo D, Tarassov K and Michnick SW. Extracting insight from noisy cellular networks. Cell, 2013. 155 (5):983-9. pdf.

Ear PH, Booth MJ, Abd-Rabbo D, Kowarzyk Moreno J, Hall C, Chen D, Vogel J and Michnick SW. Dissection of Cdk1–cyclin complexes in vivo. Proc Natl Acad Sci USA, 2013. 110 (39):15716–15721. pdf.

Messier V, Zenklusen D and Michnick SW. A nutrient-responsive pathway that determines M phase timing through control of B-cyclin mRNA stability. Cell, 2013. 153:1080-1093. pdf.

Kanshin E, Michnick SW and ThibaultDisplacement of N/Q-rich peptides on TiO2 beads enhances the depth and coverage of yeast phosphoproteome analyses. J Proteome Res, 2013. 12 (6):2905–2913. pdf.

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2012

Vallee-Belisle A and Michnick SW. Visualizing transient protein-folding intermediates by tryptophan-scanning mutagenesis. Nat Struct Mol Biol, 2012. 19 (7):731-6. pdf.

Levy ED, Michnick SW and Landry CR. Protein abundance is key to distinguish promiscuous from functional phosphorylation based on evolutionary information. Philos Trans R Soc Lond B Biol Sci, 2012. 367 (1602):2594-606. pdf.

Kanshin E, Michnick SW and ThibaultSample preparation and analytical strategies for large-scale phosphoproteomics experiments. Semin Cell Dev Biol, 2012. 23 (8):843-53. pdf.

Goyette G, Boulais J, Carruthers NJ, Landry CR, Jutras I, Duclos S, Dermine JF, Michnick SW, LaBoissiere S, Lajoie G, Barreiro L, Thibault P and Desjardins M. Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution. Mol Cell Proteomics, 2012. 11 (11):1365-77. pdf.

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2011

Stefan E, Malleshaiah MK, Breton B, Ear PH, Bachmann V, Beyermann M, Bouvier M and Michnick SW. PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades. Nat Commun, 2011. 2598. pdf.

Michnick SW, Ear PH, Landry C, Malleshaiah MK and Messier V. Protein-fragment complementation assays for large-scale analysis, functional dissection and dynamic studies of protein-protein interactions in living cells. Methods Mol Biol, 2011. 756395-425.

Freschi L, Courcelles M, Thibault P, Michnick SW and Landry CR. Phosphorylation network rewiring by gene duplication. Mol Syst Biol, 2011. 7504. pdf.

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2010

Michnick SW, Ear PH, Landry C, Malleshaiah MK and Messier V. A toolkit of protein-fragment complementation assays for studying and dissecting large-scale and dynamic protein-protein interactions in living cells. Methods Enzymol, 2010. 470335-68. pdf.

Malleshaiah MK, Shahrezaei V, Swain PS and Michnick SW. The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature, 2010. 465 (7294):101-5. pdf.

Lin CJ, Robert F, Sukarieh R, Michnick SW and Pelletier J. The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling. Cancer Res, 2010. 70 (8):3199-208. pdf.

Levy ED, Landry CR and Michnick SW. Cell signaling. Signaling through cooperation. Science, 2010. 328 (5981):983-4. pdf.

Guy J, Castonguay R, Campos-Reales Pineda NB, Jacquier V, Caron K, Michnick SW and Keillor JW. De novo helical peptides as target sequences for a specific, fluorogenic protein labelling strategy. Mol Biosyst, 2010. 6 (6):976-87. pdf.

Boulais J, Trost M, Landry CR, Dieckmann R, Levy ED, Soldati T, Michnick SW, Thibault P and Desjardins M. Molecular characterization of the evolution of phagosomes. Mol Syst Biol, 2010. 6:423. pdf.

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2009

Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M and Thomas CJ. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett, 2009. 19 (13):3686-92. pdf.

Levy ED, Landry CR and Michnick SW. How perfect can protein interactomes be?. Sci Signal, 2009. 2 (60):pe11. pdf.

Landry CR, Levy ED and Michnick SW. Weak functional constraints on phosphoproteomes. Trends Genet, 2009. 25 (5):193-7. Supplementary materials. pdf.

Halawani D, LeBlanc AC, Rouiller I, Michnick SW, Servant MJ and Latterich M. Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation. Mol Cell Biol, 2009. 29 (16):4484-94. pdf.

Ear PH and Michnick SW. A general life-death selection strategy for dissecting protein functions. Nat Methods, 2009. 6 (11):813-6. pdf.

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2008

Tarassov K, Messier V, Landry CR, Radinovic S, Serna Molina MM, Shames I, Malitskaya Y, Vogel J, Bussey H and Michnick SW. An in vivo map of the yeast protein interactome. Science, 2008. 320 (5882):1465-70. pdf.

Nyfeler B, Reiterer V, Wendeler MW, Stefan E, Zhang B, Michnick SW and Hauri HP. Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin. J Cell Biol, 2008. 180 (4):705-12. pdf.

Michnick SW and Sidhu SS. Submitting antibodies to binding arbitration. Nat Chem Biol, 2008. 4 (6):326-9.

Manderson EN, Malleshaiah M and Michnick SW. A novel genetic screen implicates Elm1 in the inactivation of the yeast transcription factor SBF. PLoS One, 2008. 3 (1):e1500. pdf.

Cheung V, Chua G, Batada NN, Landry CR, Michnick SW, Hughes TR and Winston F. Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. PLoS Biol, 2008. 6 (11):e277. pdf.

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2007

Vallee-Belisle A and Michnick SW. Multiple tryptophan probes reveal that ubiquitin folds via a late misfolded intermediate. J Mol Biol, 2007. 374 (3):791-805. pdf.

Stefan E, Aquin S, Berger N, Landry CR, Nyfeler B, Bouvier M and Michnick SW. Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo. Proc Natl Acad Sci U S A, 2007. 104 (43):16916-21. pdf.

Remy I. and Michnick SW. Application of protein-fragment complementation assays in cell biology. Biotechniques, 2007. 42 (2):137, 139, 141. pdf.

Remy I, Ghaddar G and Michnick SW. Using the beta-lactamase protein-fragment complementation assay to probe dynamic protein-protein interactions. Nat Protoc, 2007. 2 (9):2302-6.

Remy I, Campbell-Valois FX and Michnick SW. Detection of protein-protein interactions using a simple survival protein-fragment complementation assay based on the enzyme dihydrofolate reductase. Nat Protoc, 2007. 2 (9):2120-5.

Michnick SW, Ear PH, Manderson EN, Remy I. and Stefan E. Universal strategies in research and drug discovery based on protein-fragment complementation assays. Nat Rev Drug Discov, 2007. 6 (7):569-82. pdf.

Guy J, Caron K, Dufresne S, Michnick SW, Skene WG and Keillor JW. Convergent preparation and photophysical characterization of dimaleimide dansyl fluorogens: elucidation of the maleimide fluorescence quenching mechanism. J Am Chem Soc, 2007. 129 (39):11969-77. pdf.

Campbell-Valois FX and Michnick SW. Synthesis of degenerated libraries of the ras-binding domain of raf and rapid selection of fast-folding and stable clones with the dihydrofolate reductase protein fragment complementation assay. Methods Mol Biol, 2007. 352:249-74.

Campbell-Valois FX and Michnick SW. The transition state of the ras binding domain of Raf is structurally polarized based on Phi-values but is energetically diffuse. J Mol Biol, 2007. 365 (5):1559-77. pdf.

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2006

Westwick JK and Michnick SW. Protein-fragment complementation assays (PCA) in small GTPase research and drug discovery. Methods Enzymol, 2006. 407:388-401. pdf.

Remy I and Michnick SW. A highly sensitive protein-protein interaction assay based on Gaussia luciferase. Nat Methods, 2006. 3 (12):977-9.

Michnick SW, MacDonald ML and Westwick JK. Chemical genetic strategies to delineate MAP kinase signaling pathways using protein-fragment complementation assays (PCA). Methods, 2006. 40 (3):287-93. pdf.

Michnick SW. A luxRury of synthetic signals. Nat Biotechnol, 2006. 24 (6):658-60.

Michnick SW. The connectivity map. Nat Chem Biol, 2006. 2 (12):663-4.

MacDonald ML, Lamerdin J, Owens S, Keon BH, Bilter GK, Shang Z, Huang Z, Yu H, Dias J, Minami T, Michnick SW and Westwick JK. Identifying off-target effects and hidden phenotypes of drugs in human cells. Nat Chem Biol, 2006. 2 (6):329-37.

Kodadek T and Michnick SW. Introduction to monitoring and manipulating signaling networks. Mol Biosyst, 2006. 2 (12):603-4. pdf.

Jacquier V and Michnick SW. Seeing is believing. ACS Chem Biol, 2006. 1 (12):744-6. pdf.

Campbell-Valois FX, Tarassov K and Michnick SW. Massive sequence perturbation of the Raf ras binding domain reveals relationships between sequence conservation, secondary structure propensity, hydrophobic core organization and stability. J Mol Biol, 2006. 362 (1):151-71. pdf.

Benton R, Sachse S, Michnick SW and Vosshall LB. Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. PLoS Biol, 2006. 4 (2):e20. pdf.

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2005

Nyfeler B, Michnick SW and Hauri HP. Capturing protein interactions in the secretory pathway of living cells. Proc Natl Acad Sci U S A, 2005. 102 (18):6350-5. pdf.

Maxwell KL, Wildes D, Zarrine-Afsar A, De Los Rios MA, Brown AG, Friel CT, Hedberg L, Horng JC, Bona D, Miller EJ, Vallee-Belisle A, Main ER, Bemporad F, Qiu L, Teilum K, Vu ND, Edwards AM, Ruczinski I, Poulsen FM, Kragelund BB, Michnick SW, Chiti F, Bai Y, Hagen SJ, Serrano L, Oliveberg M, Raleigh DP, Wittung-Stafshede P, Radford SE, Jackson SE, Sosnick TR, Marqusee S, Davidson AR and Plaxco KW. Protein folding: defining a “standard” set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci, 2005. 14 (3):602-16. pdf.

Girouard S, Houle MH, Grandbois A, Keillor JW and Michnick SW. Synthesis and characterization of dimaleimide fluorogens designed for specific labeling of proteins. J Am Chem Soc, 2005. 127 (2):559-66. pdf.

Campbell-Valois FX, Tarassov K and Michnick SW. Massive sequence perturbation of a small protein. Proc Natl Acad Sci U S A, 2005. 102 (42):14988-93. pdf.

Campbell-Valois FX and Michnick SW. Chemical biology on PINs and NeeDLes. Curr Opin Chem Biol, 2005. 9 (1):31-7. pdf.

Tarassov K and Michnick SW. iVici: interrelational visualization and correlation interface. Genome Biol, 2005. 6 (13): R115. pdf. software.

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2004

Vallee-Belisle A, Turcotte JF and Michnick SW. raf RBD and ubiquitin proteins share similar folds, folding rates and mechanisms despite having unrelated amino acid sequences. Biochemistry, 2004. 43 (26):8447-58. pdf.

Remy I. and Michnick SW. Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol Cell Biol, 2004. 24 (4):1493-504. pdf.

Remy I and Michnick SW. A cDNA library functional screening strategy based on fluorescent protein complementation assays to identify novel components of signaling pathways. Methods, 2004. 32 (4):381-8. pdf.

Remy I, Montmarquette A and Michnick SW. PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nat Cell Biol, 2004. 6 (4):358-65. pdf.

Remy I. and Michnick SW. Mapping biochemical networks with protein-fragment complementation assays. Methods Mol Biol, 2004. 261:411-26.

Michnick SW. Proteomics in living cells. Drug Discov Today, 2004. 9 (6):262-7. pdf.

Leveson-Gower DB, Michnick SW and Ling V. Detection of TAP family dimerizations by an in vivo assay in mammalian cells. Biochemistry, 2004. 43 (44):14257-64. pdf.

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2003

Remy I and Michnick SW. Dynamic visualization of expressed gene networks. J Cell Physiol, 2003. 196 (3):419-29. pdf.

Michnick SW. Protein fragment complementation strategies for biochemical network mapping. Curr Opin Biotechnol, 2003. 14 (6):610-7. pdf.

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2002

Remy I, Galarneau A and Michnick SW. Detection and visualization of protein interactions with protein fragment complementation assays. Methods Mol Biol, 2002. 185:447-59.

Michnick SW and Valois FX. Gene function: getting specific, generally speaking. Proc Natl Acad Sci U S A, 2002. 99 (26):16513-5. pdf.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O’Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O’Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R and Sambrano GR. Participating, investigators;scientists of the Alliance for Cellular, Signaling, Overview of the Alliance for Cellular Signaling. Nature, 2002. 420 (6916):703-6. pdf.

Galarneau A, Primeau M, Trudeau LE and Michnick SW. Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions. Nat Biotechnol, 2002. 20 (6):619-22. pdf.

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2001

Subramaniam R, Desveaux D, Spickler C, Michnick SW and Brisson N. Direct visualization of protein interactions in plant cells. Nat Biotechnol, 2001. 19 (8):769-72. pdf.

Remy I. and Michnick SW. Visualization of biochemical networks in living cells. Proc Natl Acad Sci U S A, 2001. 98 (14):7678-83. pdf.

Michnick SW. Exploring protein interactions by interaction-induced folding of proteins from complementary peptide fragments. Curr Opin Struct Biol, 2001. 11 (4):472-7. pdf.

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2000

Robert F, Gagnon M, Sans D, Michnick SW and Brakier-Gingras L. Mapping of the RNA recognition site of Escherichia coli ribosomal protein S7. RNA, 2000. 6 (11):1649-59. pdf.

Michnick SW, Remy I, Campbell-Valois FX, Vallee-Belisle A and Pelletier JN. Detection of protein-protein interactions by protein fragment complementation strategies. Methods Enzymol, 2000. 328:208-30.

Michnick SW. Chemical biology beyond binary codes. Chem Biol, 2000. 7 (12):R217-21. pdf.

Arndt KM, Pelletier JN, Muller KM, Alber T, Michnick SW and Pluckthun A. A heterodimeric coiled-coil peptide pair selected in vivo from a designed library-versus-library ensemble. J Mol Biol, 2000. 295 (3):627-39. pdf.

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1999

Remy I, Wilson IA and Michnick SW. Erythropoietin receptor activation by a ligand-induced conformation change. Science, 1999. 283 (5404):990-3. pdf.

Remy I and Michnick SW. Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assays. Proc Natl Acad Sci U S A, 1999. 96 (10):5394-9. pdf.

Pelletier JN, Remy I and Michnick SW. Protein-Fragment Complementation Assays: a General Strategy for the in vivo Detection of Protein-Protein Interactions. J Biomol Tech, 1999. Accession number S0012.

Pelletier JN, Arndt KM, Pluckthun A and Michnick SW. An in vivo library-versus-library selection of optimized protein-protein interactions. Nat Biotechnol, 1999. 17 (7):683-90. pdf.

Michnick SW and Arnold FH. Itching for new strategies in protein engineering. Nat Biotechnol, 1999. 17 (12):1159-60. pdf.

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1998

Pelletier JN, Campbell-Valois FX and Michnick SW. Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments. Proc Natl Acad Sci U S A, 1998. 95 (21):12141-6. pdf.

Michnick SW and Shakhnovich E. A strategy for detecting the conservation of folding-nucleus residues in protein superfamilies. Fold Des, 1998. 3 (4):239-51. pdf.

MacKerell AD, Bashford D, Bellott M, Dunbrack RL, Evanseck JD, Field MJ, Fischer S, Gao J, Guo H, Ha S, Joseph-McCarthy D, Kuchnir L, Kuczera K, Lau FTK, Mattos C, Michnick SW, Ngo T, Nguyen DT, Prodhom B, Reiher WE, Roux B, Schlenkrich M, Smith JC, Stote R, Straub J, Watanabe M, Wiorkiewicz-Kuczera J, Yin D and Karplus M. All-atom empirical potential for molecular modeling and dynamics studies of proteins. Journal of Physical Chemistry B, 1998. 102 (18):3586-616. pdf.

Hanessian S, Luo XH, Schaum R and Michnick S. Design of secondary structures in unnatural peptides: Stable helical gamma-tetra-, hexa-, and octapeptides and consequences of alpha-substitution. Journal of the American Chemical Society, 1998. 120 (33):8569-70.

Beausoleil E, Sharma R, Michnick SW and Lubell WD. Alkyl 3-position substituents retard the isomerization of prolyl and hydroxyprolyl amides in water. Journal of Organic Chemistry, 1998. 63 (19):6572-8. pdf.

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1997

Pelletier JN and Michnick SW. A protein complementation assay for detection of protein-protein interactions in vivo. Protein Engineering, 1997. 10:89.

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Chapters

Michnick SW. From PiNs to processes: mapping out the cells machinery. In Encyclopedia of genetics, genomics, proteomics and bioinformatics, Jorde, L. B, Little, P, Dunn, M, Subramaniam, S., Eds. John Wiley & Sons: Hoboken, NJ USA, 2005, Vol. 5.

Remy I, Campbell-Volois FX, Ghaddar G and Michnick SW. Detection of Protein Interactions and Library Screening with Protein-fragment Complementation Assays. In Protein-Protein Interactions: A Molecular Cloning Manual, Second ed., Golemis, E. A, Adams,D., Eds. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York, 2005, p 637-672.

Remy I, Pelletier JN, Galarneau A and Michnick SW. Protein Interactions and Library Screening with Protein Fragment Complementation Strategies. In Protein-Protein Interactions: A Molecular Cloning Manual, First ed., Golemis, E. A., Ed. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York, 2002, p 449-475.

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Issued Patents (15 plus 60 patent applications)

Keillor JW, Michnick SW and Girouard S. Fluorescent labeling of specific protein targets in vitro and in vivo. Patent no: US 7,700,375, 2010.

Michnick SW, Pelletier JN and Remy I. Protein Fragment Complementation Assays For The Detection Of Biological Or Drug Interactions. Patent no: JP 4262778, 2009.

Michnick SW, MacDonald ML and Westwick JK. Protein fragment complementation assays in whole animals applications to drug efficacy, ADME, cancer biology, immunology, infectious disease and gene therapy. Patent no: US 7,306,914, 2007.

Michnick SW, Remy I, MacDonald ML and Lamerden J. Fragments of fluorescent proteins for protein fragment complementation assays. Patent no: US 7,166,424, 2007.

Michnick SW, Pelletier JN and Remy I. Protein Fragment Complementation Assays For The Detection Of Biological Or Drug Interactions. Patent no: US 7,160,691, 2007.

Michnick SW, Remy I, MacDonald ML, Lamerden J, Yu H and Westwick JK. Protein fragment complementation assays for high-throughput and high-content screening. Patent no: US 7,062,219, 2006.

Michnick SW, Pelletier JN and Remy I. Protein Fragment Complementation Assays For The Detection Of Biological Or Drug Interactions. Patent no: US 6,929,916, 2005.

Michnick SW, Pelletier JN and Remy I. Protein Fragment Complementation Assays For The Detection Of Biological Or Drug Interactions. Patent no: EP 0966685, 2005.

Michnick SW, Pelletier JN, Arndt K and Plückthun A. An In Vivo Library-Versus-Library Selection Of Optimized Protein-Protein Interactions. Patent no: US 6,897,017, 2005.

Brisson N and Michnick SW. Mapping molecular interactions in plants with protein fragments complementation assays. Patent no: US 6,872,871, 2005.

Michnick SW and Galarneau A. Protein fragment complementation assay (PCA) for the detection of protein-protein, protein-small molecule and protein nucleic acid interactions based on the E. coli TEM-1 .beta.-Lactamase. Patent no: US 6,828,099, 2004.

Michnick SW, Pelletier JN and Remy I. Protein Fragment Complementation Assays For The Detection Of Biological Or Drug Interactions. Patent no: US 6,428,951, 2002.

Michnick SW and Remy I. Protein Fragment Complementation Assays For The Detection Of Biological Or Drug Interactions. Patent no: US 6,294,330, 2001.

Michnick SW, Pelletier JN and Remy I. Protein Fragment Complementation Assays For The Detection Of Biological Or Drug Interactions. Patent no: US 6,270,964, 2001.

Klingmüller U, Michnick SW and Lodish H. Assays for Agents which Alter Erythropoietin Activity. Patent no: US 5, 659,012, 1997.